Article
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease.
Acta neuropathologica - 1 Sept 2020
Bandres-Ciga S, Saez-Atienzar S, Kim J J, Makarious M B, Faghri F, Diez-Fairen M, Iwaki H, Leonard H, Botia J, Ryten M, Hernandez D, Gibbs J R, Ding J, Gan-Or Z, Noyce A, Pihlstrom L, Torkamani A, Soltis A R, Dalgard C L, Scholz S W, Traynor B J, Ehrlich D, Scherzer C R, Bookman M, Cookson M, Blauwendraat C, Nalls M A, Singleton A B
Abstract excerpt
Polygenic inheritance plays a central role in Parkinson disease (PD). A priority in elucidating PD etiology lies in defining the biological basis of genetic risk. Unraveling how risk leads to disruption will yield disease-modifying therapeutic targets that may be effective. Here, we utilized a high-throughput and hypothesis-free approach to determine biological processes underlying PD using the largest currently...
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