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Article

Joint analysis of proteome, transcriptome, and multi-trait analysis to identify novel Parkinson's disease risk genes.

Aging - 17 Jan 2024

Shi Jing-Jing, Mao Cheng-Yuan, Guo Ya-Zhou, Fan Yu, Hao Xiao-Yan, Li Shuang-Jie, Tian Jie, Hu Zheng-Wei, Li Meng-Jie, Li Jia-Di, Ma Dong-Rui, Guo Meng-Nan, Zuo Chun-Yan, Liang Yuan-Yuan, Xu Yu-Ming, Yang Jian, Shi Chang-He

Abstract excerpt

Genome-wide association studies (GWAS) have identified multiple risk variants for Parkinson's disease (PD). Nevertheless, how the risk variants confer the risk of PD remains largely unknown. We conducted a proteome-wide association study (PWAS) and summary-data-based mendelian randomization (SMR) analysis by integrating PD GWAS with proteome and protein quantitative trait loci (pQTL) data from human brain, plasma...

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Identifiers

PMID: 38240717
DOI: 10.18632/aging.205444
PMCID: PMC10866412

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