Article

Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson’s disease

2026-05-28

Abstract excerpt

<title>Abstract</title> <p> To better illustrate the genetic etiology of Parkinson’s disease (PD), we integrated xQTL weights derived from bulk RNA-seq (n = 931), single-nucleus RNA-seq (n = 415), and bulk proteomics (n = 716) data of dorsolateral prefrontal cortex (DLPFC) with the largest available GWAS summary data of PD. Through integrative Omnibus TWAS and PWAS analyses, we detected risk genes whose genetic...

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Literature Corpus work: 6af9742b-c4c1-57fd-b5e9-c56ca00caf0f
DOI: 10.21203/rs.3.rs-9622597/v1

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