Article
Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk
2018-08-09
Abstract excerpt
We performed the largest genome-wide association study of PD to date, involving the analysis of 7.8M SNPs in 37.7K cases, 18.6K UK Biobank proxy-cases, and 1.4M controls. We identified 90 independent genome-wide significant signals across 78 loci, including 38 independent risk signals in 37 novel loci. These variants explained 26-36% of the heritable risk of PD. Tests of causality within a Mendelian randomization...
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Identifiers and source
- Literature Corpus work
- dc5e5b83-db43-5d5e-82a7-999fd5064f7b
- DOI
- 10.1101/388165