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Article

Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Apr 2025

Pan Lin, Yang Laiyu, Ding Weijie, Hu Yongfei, Yang Wenzhuo, Wang Jingning, Zhang Zhiyun, Fan Kangli, Sun Zhihui, Liang Yue, Lin Xiaoyue, Chen Jun, Zhang Ying

Abstract excerpt

BACKGROUND: Previous studies have reported Parkinson's disease (PD) patients usually have changes in brain image-derived phenotypes (IDPs). However, the role of genetic factors in their association and biological mechanism remains unclear. We aimed to unveil genetic and biological links between brain IDPs and PD. METHODS: Using genome-wide association study (GWAS) summary statistics and single-cell RNA sequencing...

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PMID: 40081564
DOI: 10.1016/j.pnpbp.2025.111317

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FAM13A

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