Article
Brain Proteome-Wide and Transcriptome-Wide Asso-ciation Studies, Bayesian Colocalization, and Mendelian Randomization Analyses Reveal Causal Genes of Parkinson's Disease.
The journals of gerontology. Series A, Biological sciences and medical sciences - 30 Mar 2023
Zhou Siquan, Tian Ye, Song Xuejiao, Xiong Jingyuan, Cheng Guo
Abstract excerpt
How genome-wide associated loci confer risk for Parkinson's disease is unclear. We aim to reveal causal genes through effects on brain proteins to provide new pathogenesis insights for Parkinson's disease. Proteome-wide and transcriptome-wide associations were determined by functional summary-based imputation leveraging data from genome-wide association summary (56 306 Europeans, 1.4 million controls), brain...
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