Article

Gene-drug interactions identify genomic loci that enhance statin effectiveness in lowering LDL cholesterol

2026-02-06

Abstract excerpt

Hyperlipidemia, and high low-density lipoprotein cholesterol (LDL-c) in particular, is a risk factor for cardiovascular disease, including atherosclerosis, myocardial infarction, and stroke. Nearly 200 million people worldwide take HMG-CoA reductase inhibitors, commonly known as statins, to lower their LDL-c. If statins interfere with the genetic pathways that endogenously increase the risk for hyperlipidemia, gen...

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Literature Corpus work: c9be2cb5-3d36-59fb-a4ff-0e2b8c91a76d
DOI: 10.64898/2026.02.04.703692

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