Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

Abstract excerpt

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target's expression or function, as a tool to anticipate the effect of drug action on the same target. Here we apply MR to prioritize drug targets for their causal relevance for coronary heart disease (CHD). The targets are further prioritized using independent replication,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diabetes, Cardiovascular Risks, and Lipoproteins
• Share to Genetic Associations and Epidemiology
• Share to Lipoproteins and Cardiovascular Health