Article

Human genetics suggests differing causal pathways from<i>HMGCR</i>inhibition to coronary artery disease and type 2 diabetes

2025-02-12

Abstract excerpt

<h4>Background</h4> Statins lower low-density lipoprotein cholesterol (LDL-C) and reduce the risk of coronary artery disease (CAD). However, they also increase the risk of type 2 diabetes (T2D). <h4>Methods</h4> We consider genetic variants in the region of the HMGCR gene, which encodes the target of statins, and their associations with downstream consequences of statins. We use various statistical methods to iden...

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Literature Corpus work: 718debb1-0bbc-5e3b-90f1-d1a335757b04
DOI: 10.1101/2025.02.10.25321990

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