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Article

Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.

Nature cardiovascular research - 1 Sept 2026

Wang Shaoqi, Tang Yuzhong, Sui Yang, Zhao Hongqiang, Khan Asifullah, Yin Wanqing, Chen Qiuli, Xu Tingfeng, Liu Zhaoqi, Zhang Zhang, Wang Fei, Mi Shuangli, Supriami Kelvin, Kim Min Seo, Zhou Yuan, Shi Hongjie, Xing Xudong, Yang Ying, Hao Yajing, Li Jianping, Du Jie, Yu Chenglong, Urbut Sarah, Honigberg Michael C, Natarajan Pradeep, Liu JinPing, Fahed Akl C, Wang Minxian

Abstract excerpt

Distinct genetic mechanisms govern how lipoprotein(a) (Lp(a)) and low-density lipoprotein cholesterol (LDL-C) promote atherosclerosis. It remains unclear whether targeting both provides additive cardiovascular benefits. Here we use coding loss-of-function variants in LPA and PCSK9 and genetic scores associated with Lp(a) and LDL-C levels to evaluate the effects of lowering Lp(a) and LDL-C on coronary artery...

Read the complete abstract on PubMed

Topics

Humans
Lipoprotein(a)
Coronary Artery Disease
Proprotein Convertase 9

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cholesterol, LDL

Female

UK Biobank

Genetic Risk Score

Risk Assessment

Male

Phenotype

Middle Aged

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Genetic Predisposition to Disease

Dyslipidemias

Risk Factors

Aged

Loss of Function Mutation

Source

Identifiers

PMID: 42693289
DOI: 10.1038/s44161-026-00865-9

Genes

CAD
LPA
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.PMID 42693289Read ↗

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Genetic Architecture and Clinical Outcomes of Combined Lipid Disturbances.Semantic proximity Read ↗

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A Comprehensive Review of the Genetics of Dyslipidemias and Risk of Atherosclerotic Cardiovascular DiseaseSemantic proximity Read ↗

Gene-drug interactions identify genomic loci that enhance statin effectiveness in lowering LDL cholesterolSemantic proximity Read ↗

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort.Semantic proximity Read ↗

Gene-gene interactions protect against Familial Hypercholesterolemia: effect of lost- of-function <i>PCSK9</i> variantsSemantic proximity Read ↗

The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.Semantic proximity Read ↗

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