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Article

Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.

Human genetics - 1 May 2016

Tragante Vinicius, Asselbergs Folkert W, Swerdlow Daniel I, Palmer Tom M, Moore Jason H, de Bakker Paul I W, Keating Brendan J, Holmes Michael V

Abstract excerpt

Therapeutic interventions that lower LDL-cholesterol effectively reduce the risk of coronary artery disease (CAD). However, statins, the most widely prescribed LDL-cholesterol lowering drugs, increase diabetes risk. We used genome-wide association study (GWAS) data in the public domain to investigate the relationship of LDL-C and diabetes and identify loci encoding potential drug targets for LDL-cholesterol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26946290
DOI: 10.1007/s00439-016-1647-9
PMCID: PMC4835528

Genes

CAD
PCSK9
ALDH2
APOB
CETP
HMGCR
LPA
PLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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