Article
LDL-cholesterol concentrations: a genome-wide association study.
Lancet (London, England) - 9 Feb 2008
Sandhu Manjinder S, Waterworth Dawn M, Debenham Sally L, Wheeler Eleanor, Papadakis Konstantinos, Zhao Jing Hua, Song Kijoung, Yuan Xin, Johnson Toby, Ashford Sofie, Inouye Michael, Luben Robert, Sims Matthew, Hadley David, McArdle Wendy, Barter Philip, Kesäniemi Y Antero, Mahley Robert W, McPherson Ruth, Grundy Scott M, Bingham Sheila A, Khaw Kay-Tee, Loos Ruth J F, Waeber Gérard, Barroso Inês, Strachan David P, Deloukas Panagiotis, Vollenweider Peter, Wareham Nicholas J, Mooser Vincent
Abstract excerpt
BACKGROUND: LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations. METHODS: We used genome-wide association data from up to 11,685...
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