Article

27-hydroxylation of oncosterone by CYP27A1 switchs its activity from pro-tumor to anti-tumor

2023-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha positive breast cancer (ER(+) BC) and triple negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol: 1) oxygen addition at the double bond to give α- or β-isomers of 5,6-epoxycholestanols (5,6-EC), 2) hydrolyses of the epoxide ring of 5,6-ECs...

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Literature Corpus work: c9921f95-ec3a-5eb1-b8af-12e51ed881cc
DOI: 10.1101/2023.10.10.560948

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