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Article

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

12 Oct 2017

Abstract excerpt

Breast cancer (BC) remains the primary cause of death from cancer among women worldwide. Cholesterol-5,6-epoxide (5,6-EC) metabolism is deregulated in BC but the molecular origin of this is unknown. Here, we have identified an oncometabolism downstream of 5,6-EC that promotes BC progression independently of estrogen receptor α expression. We show that cholesterol epoxide hydrolase (ChEH) metabolizes 5,6-EC into...

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PMID: 29078321
DOI: 10.1073/pnas.1707965114

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