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Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1

1 Dec 1999

Abstract excerpt

Oxysterol 7alpha-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism. The cloned human oxysterol 7alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the...

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PMID: 10588945
DOI: 10.1016/s0022-2275(20)32094-0

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