Article
The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies.
Archives of gynecology and obstetrics - 1 May 2015
Ruan Xiangyan, Seeger Harald, Wallwiener Diethelm, Huober Jens, Mueck Alfred O
Abstract excerpt
PURPOSE: Two main estradiol metabolites have different biological behavior with tumorigenic features of 16-OHE1 and antiproliferative characteristics of 2-OHE1. We investigated the ratio of these estradiol metabolites in pre- and postmenopausal patients with breast cancer (BC) within two case-control studies. METHODS: From 41 premenopausal patients with (cases) and without (controls N = 211) BC and 207...
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