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Article

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.

British journal of cancer - 1 Jan 2017

Sood Deepti, Johnson Nichola, Jain Pooja, Siskos Alexandros P, Bennett Mark, Gilham Clare, Busana Marta Cecilia, Peto Julian, Dos-Santos-Silva Isabel, Keun Hector C, Fletcher Olivia

Abstract excerpt

BACKGROUND: Endogenous sex hormones are well-established risk factors for breast cancer; the contribution of specific oestrogen metabolites (EMs) and/or ratios of specific EMs is less clear. We have previously identified a CYP3A7*1C allele that is associated with lower urinary oestrone (E1) levels in premenopausal women. The purpose of this analysis was to determine whether this allele was associated with...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28072767
DOI: 10.1038/bjc.2016.432
PMCID: PMC5294487

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