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Cyclin D1 regulates hepatic estrogen and androgen metabolism

26 Mar 2010

Abstract excerpt

Cyclin D1 is a cell cycle control protein that plays an important role in regenerating liver and many types of cancer. Previous reports have shown that cyclin D1 can directly enhance estrogen receptor activity and inhibit androgen receptor activity in a ligand-independent manner and thus may play an important role in hormone-responsive malignancies. In this study, we examine a distinct mechanism by which cyclin...

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PMID: 20338923
DOI: 10.1152/ajpgi.00471.2009

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