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5,6-Epoxycholestanols Metabolism and Functions: Defining the Epoxycholestanoid (EChA) Family

2026-01-12

Abstract excerpt

The oxidation of cholesterol at the Δ⁵ double bond generates 5,6-epoxycholestanols (5,6-ECs), which exist as two diastereoisomers, 5,6α-EC and 5,6β-EC. These metabolites define a distinct branch of sterol metabolism that integrates redox chemistry with receptor signaling. Once considered artefactual autoxidation products, 5,6-ECs are now recognized as regulated intermediates arising from enzymatic, inflammatory, a...

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Literature Corpus work
02e0ff92-5176-57b1-b41e-e2232b6b1bc2
DOI
10.22541/au.176824984.47866037/v1
Open publication

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5,6-Epoxycholestanols Metabolism and Functions: Defining the Epoxycholestanoid (EChA) FamilyDOI 10.22541/au.176824984.47866037/v1
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