Article

Adipocytes in tumour microenvironment promote chemoresistance in TNBC through oxysterols

2025-04-26

Abstract excerpt

<h4>Objective</h4> Triple-negative breast cancer (TNBC) patients with excess adipose tissue experience poorer disease-free survival than those with a healthy body mass index. Adipocytes, abundant in mammary tissue, store and release cholesterol, which can be hydroxylated to form oxysterols. These cholesterol derivatives activate the liver X receptor (LXR) pathway. This study tested the hypothesis that adipocytes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa6920a9-6705-522f-ae62-8625a0b9dcce
DOI: 10.1101/2025.04.24.650225

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adipocytes in tumour microenvironment promote chemoresistance in TNBC through oxysterolsDOI 10.1101/2025.04.24.650225Read

Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes.Semantic proximity Read

Single-cell analysis of white adipose tissue reveals the tumor-promoting adipocyte subtypesSemantic proximity Read

Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosisSemantic proximity Read

Multi-omics characterization of lymphedema-induced adipose tissue from breast cancer patientsSemantic proximity Read

Adipocyte mesenchymal transition contributes to mammary tumor progressionSemantic proximity Read

Single-cell RNA-sequencing reveals a unique landscape of the tumor microenvironment in obesity-associated breast cancerSemantic proximity Read

Adipocyte is a non-trivial, dynamic partner of breast cancer cellsSemantic proximity Read

Obesity-associated changes in molecular biology of primary breast cancerSemantic proximity Read

Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulationSemantic proximity Read

Single-cell RNA-sequencing reveals a unique landscape of the tumor microenvironment in obesity-associated breast cancerSemantic proximity Read

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasisSemantic proximity Read

TUMOR–PRE-ADIPOCYTE CROSSTALK SUSTAINS BREAST CANCER GROWTH VIA RET SIGNALLINGSemantic proximity Read