Article

The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2

2020-03-17

Abstract excerpt

<h4>SUMMARY</h4> The rapid and escalating spread of SARS coronavirus 2 (SARS-CoV-2) poses an immediate public health emergency. The viral spike protein S binds ACE2 on host cells to initiate molecular events that release the viral genome intracellularly. Soluble ACE2 inhibits entry of both SARS and SARS-2 coronaviruses by acting as a decoy for S binding sites, and is a candidate for therapeutic, prophylactic and...

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Literature Corpus work: c980b091-d029-5385-b3d6-d6a4ca255779
DOI: 10.1101/2020.03.16.994236

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