Article
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Science (New York, N.Y.) - 4 Sept 2020
Chan Kui K, Dorosky Danielle, Sharma Preeti, Abbasi Shawn A, Dye John M, Kranz David M, Herbert Andrew S, Procko Erik
Abstract excerpt
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine 90-glycosylation motif and at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.