Article

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein

2020-09-17

Abstract excerpt

Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can have a major impact in leveraging ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleotide variants (SNVs) that are likely to have altered recognition by the virus, and make the complementary discovery tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3acb7033-6d14-52d9-bdd8-c03665b55634
DOI: 10.1101/2020.09.17.301861

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike proteinDOI 10.1101/2020.09.17.301861Read

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein.Semantic proximity Read

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infectionSemantic proximity Read

Structural Genetics of circulating variants affecting the SARS-CoV-2 Spike / human ACE2 complexSemantic proximity Read

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein.Semantic proximity Read

Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility.Semantic proximity Read

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity.Semantic proximity Read

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity.Semantic proximity Read

Structural modeling of the SARS-CoV-2 Spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibilitySemantic proximity Read

Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.Semantic proximity Read

The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2Semantic proximity Read

Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19Semantic proximity Read

SARS-CoV-2 Spike receptor-binding domain with a G485R mutation in complex with human ACE2Semantic proximity Read