Article

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

2020-10-19

Abstract excerpt

<h4>ABSTRACT</h4> The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high affinity, potently neutralize infection and, due to close similarity with the natural receptor, hold out the promise of being broadly active against virus variants without opportunity for escape. Here, we directly test thi...

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Literature Corpus work: 4dea3df1-0c5d-5266-b402-f05d030ae48f
DOI: 10.1101/2020.10.18.344622

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