Article

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

2021-12-30

Abstract excerpt

<h4>Summary</h4> The SARS-CoV-2 Omicron with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures of the Spike (S) from Omicron reveals amino acid substitutions forging new interactions that stably maintain an “active” conformation for receptor recognition. The relatively more compact domain organization confers improved stability and enhances attachment but compromises the efficiency...

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Literature Corpus work: cf4c7961-b225-55e6-8f3d-7de966fbc529
DOI: 10.1101/2021.12.29.474402

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