Article

High-efficiency likelihood inference of shared proteomic architectures across 50 complex human traits

2025-03-17

Abstract excerpt

Advancements in genetic correlation estimation have elucidated genome-wide pleiotropy’s influence on phenotypic correlations among human complex traits and diseases. However, the role of proteomic domains in these correlations remains underexplored. Traditional genetic correlation analysis assumptions, including the minute effects of SNPs and their linkage disequilibrium, do not suit proteomic data. We present a n...

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Literature Corpus work: c92e668f-835b-550d-b53e-c9e143f23de1
DOI: 10.1101/2025.03.16.643065

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