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Article

High-definition likelihood inference of genetic correlations across human complex traits.

Nature genetics - 1 Aug 2020

Ning Zheng, Pawitan Yudi, Shen Xia

Abstract excerpt

Genetic correlation is a central parameter for understanding shared genetic architecture between complex traits. By using summary statistics from genome-wide association studies (GWAS), linkage disequilibrium score regression (LDSC) was developed for unbiased estimation of genetic correlations. Although easy to use, LDSC only partially utilizes LD information. By fully accounting for LD across the genome, we...

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PMID: 32601477
DOI: 10.1038/s41588-020-0653-y

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