Article

Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction

2025-07-11

Abstract excerpt

Plasma proteins capture dynamic physiological processes and may offer more immediate insight into disease risk than static genetic predictors. We evaluated the predictive utility of proteomic risk scores (ProRS) versus polygenic risk scores (PRS) across 301 phenotypes in 39,843 participants from the UK Biobank Pharma Proteomics Project. ProRS, trained on prevalent cases, were tested for incident disease and benchm...

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Literature Corpus work: 288c4624-e538-5948-ba1c-d0a91d6efb4d
DOI: 10.1101/2025.07.10.25331242

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