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Article

High-definition likelihood inference of genetic colocalization reveals protein biomarkers for human complex diseases.

GigaScience - 21 Jan 2026

Li Yuying, Zhai Ranran, Yang Zhijian, Li Ting, Pawitan Yudi, Shen Xia

Abstract excerpt

BACKGROUND: Genetic colocalization analysis is essential for understanding the shared genetic basis between phenotypic traits. Such an analysis is particularly useful for identifying plasma proteins with potential as therapeutic targets or clinical biomarkers. Improvements to existing tools are needed for more accurate inference of potentially causal biomarkers. FINDINGS: We develop high-definition likelihood for...

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PMID: 41574934
DOI: 10.1093/gigascience/giaf155
PMCID: PMC12916012

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