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Article

Correlations between complex human phenotypes vary by genetic background, gender, and environment.

Cell reports. Medicine - 20 Dec 2022

Elgart Michael, Goodman Matthew O, Isasi Carmen, Chen Han, Morrison Alanna C, de Vries Paul S, Xu Huichun, Manichaikul Ani W, Guo Xiuqing, Franceschini Nora, Psaty Bruce M, Rich Stephen S, Rotter Jerome I, Lloyd-Jones Donald M, Fornage Myriam, Correa Adolfo, Heard-Costa Nancy L, Vasan Ramachandran S, Hernandez Ryan, Kaplan Robert C, Redline Susan, Sofer Tamar

Abstract excerpt

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both...

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Identifiers

PMID: 36513073
DOI: 10.1016/j.xcrm.2022.100844
PMCID: PMC9797952

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