Article

Cross-ancestry information transfer framework improves protein abundance prediction and protein-trait association identification

2025-08-16

Abstract excerpt

Genetics-informed proteome-wide association studies (PWAS) provide an effective way to map the complex molecular landscape of biological mechanisms for complex diseases. PWAS relies on an ancestry-matched reference panel to model protein expression using genetic variants as features and determine the protein’s impact on phenotype. However, reference panels from underrepresented populations remain relatively limite...

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Literature Corpus work: 3c6d16d0-e759-5e02-a3ff-05b110f07b20
DOI: 10.1101/2025.08.13.670235

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