Article

Integrating Genomic and Proteomic Data Improves Complex Trait Prediction in Diverse Populations

2026-08-12

Abstract excerpt

Polygenic risk scores (PRS) capture inherited susceptibility, and circulating proteins reflect downstream biological processes for complex traits and diseases. Proteomic risk scores (ProRS) may provide complementary information, although their added value beyond PRS, robustness to proteomic missingness and stability across populations and disease stages remain unclear. We developed an imputation and ensemble frame...

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Literature Corpus work: 3d112e7d-a571-5489-b4e3-e77c84d74918
DOI: 10.64898/2026.08.10.26360136

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