Article

Co-expression-wide association studies link genetically regulated interactions with complex traits

2024-10-04

Abstract excerpt

Transcriptome- and proteome-wide association studies (TWAS/PWAS) have proven successful in prioritizing genes and proteins whose genetically regulated expression modulates disease risk, but they ignore potential co-expression and interaction effects. To address this limitation, we introduce the co-expressionwide association study (COWAS) method, which can identify pairs of genes or proteins whose genetically regul...

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Literature Corpus work: 00739035-fad5-54fe-988a-82b4c73f8b2e
DOI: 10.1101/2024.10.02.24314813

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