Article

XLID Syndrome Gene Med12 Promotes Ig Isotype Switching through Chromatin Modification and Enhancer RNA regulation

2022-06-17

Abstract excerpt

<h4>ABSTRACT</h4> The transcriptional co-activator Med12 regulates gene expression through the function of its kinase module and by interacting with the larger Mediator complex and associated RNA Polymerase II (RNAPII). Here, we show a kinase module-independent function of Med12 in antibody class switching recombination (CSR). Med12 is essential for IgH 3’ regulatory region (3’RR) or super-enhancer activation and...

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Literature Corpus work: c924d18a-3e7b-5b8d-9815-1edc1f33c1b9
DOI: 10.1101/2022.06.14.496024

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