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Rad52 mediates class-switch DNA recombination to IgD

21 Feb 2022

Abstract excerpt

Abstract In B cells, IgD is expressed together with IgM through alternative splicing of primary V H DJ H -C μ -s-m-Cδ-s-m RNAs, and also through IgD class switch DNA recombination (CSR) via double-strand DNA breaks (DSB) and synapse of Sμ with σ δ . How such DSBs are resolved is still unknown, despite our previous report showing that Rad52 effects the ‘short-range’ microhomology-mediated synapsis of intra-Sμ...

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PMID: 35190531
DOI: 10.1038/s41467-022-28576-2

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