Article
An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.
The Journal of allergy and clinical immunology - 1 Apr 2015
Kracker Sven, Di Virgilio Michela, Schwartzentruber Jeremy, Cuenin Cyrille, Forveille Monique, Deau Marie-Céline, McBride Kevin M, Majewski Jacek, Gazumyan Anna, Seneviratne Suranjith, Grimbacher Bodo, Kutukculer Necil, Herceg Zdenko, Cavazzana Marina, Jabado Nada, Nussenzweig Michel C, Fischer Alain, Durandy Anne
Abstract excerpt
BACKGROUND: Immunoglobulin class-switch recombination defects (CSR-D) are rare primary immunodeficiencies characterized by impaired production of switched immunoglobulin isotypes and normal or elevated IgM levels. They are caused by impaired T:B cooperation or intrinsic B cell defects. However, many immunoglobulin CSR-Ds are still undefined at the molecular level. OBJECTIVE: This study's objective was to...
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