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Article

Three-dimensional architecture of the IgH locus facilitates class switch recombination.

Annals of the New York Academy of Sciences - 1 Sept 2012

Kenter Amy L, Feldman Scott, Wuerffel Robert, Achour Ikbel, Wang Lili, Kumar Satyendra

Abstract excerpt

Immunoglobulin (Ig) class switch recombination (CSR) is responsible for diversification of antibody effector function during an immune response. This region-specific recombination event, between repetitive switch (S) DNA elements, is unique to B lymphocytes and is induced by activationinduced deaminase (AID). CSR is critically dependent on transcription of noncoding RNAs across S regions. However, mechanistic...

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Source

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Identifiers

PMID: 22954221
DOI: 10.1111/j.1749-6632.2012.06604.x
PMCID: PMC3442954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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