Article
Context-dependent toxicity of human tau isoforms in a Drosophila tauopathy model.
Biology open - 15 Jul 2026
Ivanova Yelena, Ramirez-Moreno Miguel, Liu Jie, Abtahi Leila, Wu Baidong, Cooper Amber S, Wang Zengbo, Allan Douglas W, Mudher Amritpal, Comeault Aaron A, Sivanatharajah Lovesha
Abstract excerpt
Tauopathies are characterised by progressive deterioration of brain regions due to abnormal accumulation of microtubule-associated protein tau (MAPT). Alternative splicing of MAPT pre-mRNA produces six isoforms, classified as 3R or 4R depending on whether they contain three or four microtubule-binding repeats. Although many tauopathies are 3R or 4R specific, individual isoform contributions to neurotoxicity...
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