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Article

Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy.

Neurobiology of disease - 1 Sept 2017

Sealey Megan A, Vourkou Ergina, Cowan Catherine M, Bossing Torsten, Quraishe Shmma, Grammenoudi Sofia, Skoulakis Efthimios M C, Mudher Amritpal

Abstract excerpt

Tau exists as six closely related protein isoforms in the adult human brain. These are generated from alternative splicing of a single mRNA transcript and they differ in the absence or presence of two N-terminal and three or four microtubule binding domains. Typically all six isoforms have been considered functionally similar. However, their differential involvement in particular tauopathies raises the...

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Identifiers

PMID: 28502805
DOI: 10.1016/j.nbd.2017.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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