Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.

Abstract excerpt

Tauopathies are a heterogeneous group of neurodegenerative dementias involving perturbations in the levels, phosphorylation, or mutations of the microtubule-binding protein Tau. The heterogeneous pathology in humans and model organisms suggests differential susceptibility of neuronal types to wild-type (WT) and mutant Tau. WT and mutant human Tau-encoding transgenes expressed pan-neuronally in the Drosophila CNS...

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• B7-1 Antigen
• Discrimination Learning
• Embryo, Nonmammalian
• Memory
• Mushroom Bodies