Article

Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in <i>Drosophila</i>

2024-12-23

Abstract excerpt

<h4>Background</h4> Disease-modifying therapies for tauopathies like Alzheimer’s disease have targeted Tau hyperphosphorylation and aggregation, as both pathological manifestations are implicated in Tau-mediated toxicity. However, the relative contributions of these pathology-linked changes to Tau neurotoxicity remain unclear. <h4>Methods</h4> Leveraging the genetic tractability of Drosophila , we generated mul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e57ba1da-8bc5-5f3b-861c-416867b7d6e0
DOI: 10.1101/2024.12.22.629946

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in <i>Drosophila</i>DOI 10.1101/2024.12.22.629946Read

Tau toxicity is gated through the 306VQIVYK311 domain but through mechanisms not entirely dependent on Tau aggregationSemantic proximity Read

Context-dependent toxicity of human Tau isoforms in a <i>Drosophila</i> tauopathy modelSemantic proximity Read

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer’s disease and other TauopathiesSemantic proximity Read

The <i>Drosophila</i> wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discoverySemantic proximity Read

MARK4 with an Alzheimer’s disease-related mutation promotes tau hyperphosphorylation directly and indirectly and exacerbates neurodegenerationSemantic proximity Read

Are Tau Aggregates Toxic or Protective in Tauopathies?Semantic proximity Read

A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.Semantic proximity Read

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.Semantic proximity Read

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicitySemantic proximity Read

Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.Semantic proximity Read

Context-dependent toxicity of human tau isoforms in a Drosophila tauopathy model.Semantic proximity Read

Age dependent trans-cellular propagation of human tau aggregates in <i>Drosophila</i> disease modelsSemantic proximity Read