Back to search

Article

The <i>Drosophila</i> wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery

2025-05-23

Abstract excerpt

Tau protein contributes to microtubule stability, which is disrupted in Alzheimer’s disease and other Tauopathies. In these diseases, Tau molecules become hyperphosphorylated, misfolded and aggregated, propagating pathology across the brain. Studies dissecting disease mechanisms or screening disease-modifying therapies rely on animal models that unveil pathogenic events in vivo but also take several weeks or mont...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
928a8244-7d31-51be-b65e-36d702f1d958
DOI
10.1101/2025.05.21.655273
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The <i>Drosophila</i> wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discoveryDOI 10.1101/2025.05.21.655273
Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery.Semantic proximity
Drosophila Models of Tauopathies: What Have We Learned?Semantic proximity
Context-dependent toxicity of human Tau isoforms in a <i>Drosophila</i> tauopathy modelSemantic proximity
Sexually dimorphic behavioural signatures of tau toxicity in adult <i>Drosophila</i>Semantic proximity
Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.Semantic proximity
Studying tauopathies in Drosophila: A fruitful model.Semantic proximity
Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.Semantic proximity
From fruit fly to bedsideSemantic proximity
Age dependent trans-cellular propagation of human tau aggregates in <i>Drosophila</i> disease modelsSemantic proximity
Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in <i>Drosophila</i>Semantic proximity
<i>Drosophila</i> as an <i>In Vivo</i> Model for Human Neurodegenerative DiseaseSemantic proximity
A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathiesSemantic proximity
Select a neighboring publication to make it the new centre.