Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.

Abstract excerpt

Accumulations of Tau, a microtubule-associated protein (MAP), into neurofibrillary tangles is a hallmark of Alzheimer's disease and other tauopathies. However, the mechanisms leading to this pathology are still unclear: the aggregates themselves could be toxic or the sequestration of Tau into tangles might prevent Tau from fulfilling its normal functions, thereby inducing a loss of function defect. Surprisingly,...

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• Animals, Genetically Modified
• Axons
• Gene Knockdown Techniques
• Microtubules
• Nerve Degeneration