Article
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Jan 2018
Bardai Farah H, Wang Liqun, Mutreja Yamini, Yenjerla Mythili, Gamblin T Chris, Feany Mel B
Abstract excerpt
The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau. In vitro, FTDP-17 mutant versions of tau can reduce microtubule binding and increase the aggregation of tau, but the mechanism by which these mutations promote disease in vivo is not clear....
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