Article

Tau toxicity is gated through the 306VQIVYK311 domain but through mechanisms not entirely dependent on Tau aggregation

2026-05-07

Abstract excerpt

<title>Abstract</title> Disease-modifying therapies for Tauopathies like Alzheimer’s disease have targeted Tau hyperphosphorylation and aggregation, as both pathological manifestations are implicated in Tau-mediated toxicity. More recently there has been a renewed interest in Tau conformation which appears to influence its toxic potential. However, the impact of Tau hyper-phosphorylation on its eventual conf...

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Literature Corpus work: 5ca98701-3da5-5a19-a8e5-73dde882a3c4
DOI: 10.21203/rs.3.rs-8909841/v1

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