Article

Large-scale prediction of transcription factor binding across human cell types informs regulatory genomics and reveals promiscuous occupancy associated with chromatin contacts

2026-06-18

Abstract excerpt

Our understanding of the mechanisms regulating gene expression has been hampered by our limited knowledge of which transcription factors (TFs) bind where in the genome, which is highly cell type-specific. While genome-wide TF binding can be experimentally assayed for individual TFs in individual cell types, profiling the full combinations of over 1600 TFs in hundreds of cell types is beyond practical reach. In thi...

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Literature Corpus work: aca4f2c1-aad4-52a4-92d2-092f9d5088df
DOI: 10.64898/2026.06.16.732527

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