Article

Identification of methylation-sensitive human transcription factors using meSMiLE-seq

2024-11-12

Abstract excerpt

Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assayed 284 mostly poorly characterized, putative human TFs using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), revealing 72 new DNA binding motifs. To investigate whether some of the 158 TFs for which we did not find motifs preferabl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bd5b1bd-6d94-52ac-8a4e-1b4520c190c2
DOI: 10.1101/2024.11.11.619598

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of methylation-sensitive human transcription factors using meSMiLE-seqDOI 10.1101/2024.11.11.619598Read

SEMplMe: A tool for integrating DNA methylation effects in transcription factor binding affinity predictionsSemantic proximity Read

TFBSshape: an expanded motif database for DNA shape features of transcription factor binding sites.Semantic proximity Read

Genome-wide quantification of the effects of DNA methylation on human gene regulationSemantic proximity Read

Factorbook: an Updated Catalog of Transcription Factor Motifs and Candidate Regulatory Motif SitesSemantic proximity Read

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factorsSemantic proximity Read

MOCCS profile analysis clarifies the cell type dependency of transcription factor-binding sequences and cis-regulatory SNPs in humansSemantic proximity Read

A proteocistromic atlas of 216 human disease-relevant transcription factorsSemantic proximity Read

Chromatin regulates genome-wide transcription factor binding affinitiesSemantic proximity Read

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteinsSemantic proximity Read

A domain-resolution map of <i>in vivo</i> DNA binding reveals the regulatory consequences of somatic mutations in zinc finger transcription factorsSemantic proximity Read

Virtual ChIP-seq: predicting transcription factor binding by learning from the transcriptomeSemantic proximity Read

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factorsSemantic proximity Read