Article

Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders

2024-08-26

Abstract excerpt

GATA1 is a crucial transcription factor involved in hematopoiesis, and mutations in this gene are linked to severe hematological disorders, including anemia, thrombocytopenia, Down-syndrome related transient abnormal myelopoiesis (DS-TAM) and acute megakaryocytic leukemia (DS- AMKL). Despite significant clinical interest in the molecular level characterization of GATA1 mutations, a comprehensive understanding of t...

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Literature Corpus work: bca31d1c-e681-53ad-be25-f09f68e75e3c
DOI: 10.1101/2024.08.26.609639

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