Article

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network

2020-12-14

Abstract excerpt

<h4>Summary</h4> Genetic variations in CD2-associated protein (CD2AP) predispose to Alzheimer’s disease (AD) but the underlying mechanisms remain unknown. Here, we show that a cerebrovascular loss of CD2AP is associated with cognitive decline in AD and that genetic downregulation of CD2AP in brain endothelial cells impairs memory function in two distinct mouse models. Mice with reduced CD2AP in brain microvessels...

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Literature Corpus work: c8fc4773-69bb-5ddb-8ba9-53697e9bcc7f
DOI: 10.1101/2020.12.10.419598

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