Article

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profiling

2025-03-10

Abstract excerpt

Alzheimer’s disease (AD) affects 40 million individuals globally and is characterized by the accumulation of amyloid-beta (Aβ) proteins, which aggregate and form plaques. BBB dysfunction drives AD cerebrovascular pathology and BBB integrity is maintained by neurovascular unit (NVU). Specifically, within the NVU, the cerebral endothelial cells maintain vascular homeostasis. In this study, we isolated endothelial-en...

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Literature Corpus work: 2b52d159-7321-5c5b-8bde-e0933774b49e
DOI: 10.1101/2025.03.03.640886

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